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Recombinant Human PDGF-CC (HEK293-expressed)
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性状 | Recombinant Human PDGF-CC (HEK293-expressed) 属于 PDGF 家族,能够与 PDGFR-α 和 PDGFR-β 结合,为有效的血管生成因子。
Synonyms rHuPDGF-CC; PDGF-C; SCDGF ; 重组人血小板衍生生长因子-CC (HEK293 细胞表达) Species Human Source HEK 293 Accession Q9NRA1 Gene ID 56034 Molecular Weight 15-19 kDa AA Sequence VVDLNLLTEE VRLYSCTPRN FSVSIREELK RTDTIFWPGC LLVKRCGGNC ACCLHNCNEC QCVPSKVTKK YHEVLQLRPK TGVRGLHKSL TDVALEHHEE CDCVCRGSTG G Biological Activity The ED50 is <1 ng/mL as measured by 3T3 cells. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS. Endotoxin Level <0.2 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human PDGF-CC (HEK293-expressed) (rHuPDGF-CC) to 100 μg/mL using ddH2O or PBS. Storage & Stability Lyophilized recombinant Human PDGF-CC (HEK293-expressed) (rHuPDGF-CC) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background PDGF-CC is a relatively new member of the PDGF family, abundantly expressed by different types of cells, such as tumor cells, endothelial cells (ECs), vascular smooth muscle cells (VSMCs), pericytes, fibroblasts, and macrophages. PDGF-CC binds to PDGFR-α and PDGFR-β, which are also expressed by many different cell types, including tumor cells, VSMCs, pericytes, and fibroblasts, all of which play important roles in angiogenesis. PDGF-CC is a potent angiogenic factor[1]. |
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